Individuality and the Genome

Individuality and the Genome. A COLONY OF GENETICALLY IDENTICAL E. COLI IS ACTUALLY A MOB OF ‘INDIVIDUALS’.

UNDERSTANDING INDIVIDUALITY: 

Individuality and the Genome. Even among simple forms of life, like the common bacterium E. coli, genetics only partly determines what any one organism is like. E. coli expresses its individuality in many ways. All the bacilli above are genetically identical, but the shades show differences in the production of proteins that digest lactose.Credit…Dr. Michael Elowitz

Dr. Michael Elowitz, Physicist at California Institute of Technology has conducted experiments on colonies of genetically identical (Clones) E. coli bacteria under identical experimental conditions and has discovered that the clones behave in different ways which could be viewed as an expression of ‘individuality’.

Individuality and the Genome. The Law of Individuality governs all Individual Living Things.

E. coli bacteria in billions populate our intestines. Typical E. coli bacillus has about 4,000 genes. Human cells have about 20,000 genes. The bacteria have fingerprints of their own and even when they share the exact same genome, they could still be identified as ‘individuals’.

Individuality and the Genome. Dr. Michael Elowitz and Dr. Long Cai are developing a platform through which cells can self-record their lineage and molecular event histories directly into their own DNA as they create new tissues, particularly in the brain. This research will help to address how individual cells in a developing embryo diversify into many distinct cell types, each playing its unique role in the organism.

The key to understanding E. coli’s fingerprints is to recognize that the bacteria are not simple machines. Unlike wires and transistors, E. coli’s molecules are floppy, twitchy and unpredictable. In an electronic device, like a computer or a radio, electrons stream in a steady flow through the machine’s circuits, but the molecules in E. coli jostle and wander. When E. coli begins using a gene to make a protein, it does not produce a smoothly increasing supply. It spurts out the proteins in fits and starts. One clone may produce half a dozen copies of a protein in an hour, while a clone right next to it produces none.

Michael Elowitz, a physicist at Caltech, put these bursts on display in an elegant experiment. He and his colleagues incited E. coli to produce its proteins for feeding on lactose. Dr. Elowitz and his colleagues added extra genes to the bacteria so that when they made lactose-digesting proteins, they also released light.

The bacteria, Dr. Elowitz found, did not produce a uniform glow. They flickered, sometimes brightly, sometimes dimly. And when Dr. Elowitz took a snapshot of the colony, it was not a uniform sea of light. Some microbes were dark at that moment while others shone at full strength.

At the very least, E. coli’s individuality should be a warning to those who would put human nature down to any sort of simple genetic determinism. Living things are more than just programs run by genetic software. Even in minuscule microbes, the same genes and the same genetic network can lead to different fates.

The bacteria have fingerprints of their own and even when they share the same genome, they could still be identified as individuals.

Individuality and the Genome. Man is constituted as a Biotic Community of socially interacting cells and microbes

Humans differ from one another in too many different ways and it is hard to count. The current human population of over six billion could be identified as the same number of individuals. Each human being has an unique genome of his own. There are millions of typographical differences between one genome and another human genome. Even identical twins are not truly identical at all as identical genes in our cells can behave differently. 

Living entities are not like simple machines. When we use a gene to make a protein, the gene may not produce a smoothly increasing supply of that protein. The gene tends to work in fits and starts and spurts out the protein. Identical genes can behave differently as the gene makes protein or remains silent depending upon the ‘Methyl’ groups that cap the DNA strands and function as ‘transducers’. These ‘Methyl’ groups sometimes fall off of DNA or become attached to new spots. Hence genetically identical individuals can have different physical identities in the natural world. The protein molecules that make up living entities, turn them into individuals. 

THE IRRELEVANCE OF EVOLUTION: 

Individuality and the Genome: CHARLES DARWIN’S ORIGIN OF SPECIES (1859) PROPOSES A MECHANISTIC, NONPURPOSIVE ACCOUNT OF EVOLUTION AS THE PRODUCT OF THE NATURAL SELECTION OF RANDOMLY PRODUCED GENETIC MUTATIONS.

In the natural world, all living entities exist as individuals and express their individuality. The Theory of Evolution proposes that a species can descend or arrive to become a new species by changing its genome in a gradual and incremental manner using a mechanism that is described as ‘ natural selection ‘. The mechanism of natural selection operates via a process of random and unguided mutations in the genetic code that changes the genome and eventually produces the ‘biodiversity’ that we witness in the natural world.

Individuality and the Genome. The phenomenon of Diversity must be studied beyond the realm of genes, genetic codes, and genomes. Cytoplasm and its organs must be studied to understand the physiological basis of Diversity

This Theory of Evolution has no relevance to the ultimate identity of each individual member of a given species. This identity is dictated by the interplay between the various components of each individual cell and its interactions with other cells. With the same genomes or different genomes, the living entities can only exist as individuals and they have no other choice. The evolutionary connections are not relevant to this identity. To understand the phenomenon of biodiversity, we will be forced to look at each individual member of each given species. 

THE LAW OF INDIVIDUALITY: 

Individuality and the Genome. The Law of Individuality formulates the phenomenon of Human Individuality.

I propose that the Law of Individuality governs all the living entities and is manifested in various biological phenomena. The genes and the genetic code function in accordance with the Law of Individuality. I would describe Individuality as a Trade Mark. It is the characteristic of a biological entity. Genes and the genetic codes are the tools that an organism uses to express its Individuality. Each organism assembles its own kind of protein molecules to define its identity and to defend its existence in the natural world. 

Individuality and the Genome. The Law of Individuality formulates the phenomenon of Human Individuality.

Published by WholeDude

Whole Man - Whole Theory: I intentionally combined the words Whole and Dude to describe the Unity of Body, Mind, and Soul to establish the singularity called Man.

Join the Conversation

2 Comments

  1. I am very glad to read the contents of this message. The notion of an individual conscious living being is one the most important mysteries in the creation. Whether it is a human being or a cell it excites one’s admiration. Does this individuality suggest any hitherto unknown ‘force’ that operates on the material componets of the individual?

    Like

    1. Thanks for your remarks. Yes indeed, there are two other Fundamental Forces that operate in the universe and they specifically influence all living entities. I have described ‘Krupa’ and ‘Maya’ as Fundamental Forces. I would be happy to share those two pages with you.

      Like

Leave a comment

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: